Two hits of the initial P1 six hits are peculiar in that they have a 4-aminopyrazole ring, albeit in different flips, but both with the acceptor aza close to S105. The latter flips though.
https://fragalysis.diamond.ac.uk/viewer/react/projects/3575/3082
No direct derivatives are available with the 4-aminopyrazole ring substituted on both sides:
https://arthor.docking.org/index.html#real-database-22q1/sub:qi/s/Cc1c(N)n(C)nc1C(N)=O
Enamine is limited in terms of Huisgen-cycloaddition triazole products. So that is unlikely to be a productive scaffold. But others might be?